Can You Donate Blood If You Have Alpha Thalassemia

Thalassemia: What It Is & Can A Person Suffering From It Donate Blood Healthians

My bloodwork is always abnormal so I would not want to risk passing thalessemia to anyone else. I am really not sure about the organ donation issue. The disorder which requires regular blood transfusion can be cured if the patient gets the right donor for a bone marrow transplant. However, the success rate remains awfully low at 3 to 5 percent. With appropriate investigations, thalassemia, its type and severity can be diagnosed. Routine blood tests can detect anaemia but more specialised tests help to diagnose thalassemia.

  • Antibodies to hepatitis B, hepatitis C, and HIV should also be determined.
  • This can cause symptoms such as tiredness and pale skin, but may only be picked up with a blood test.
  • Both of these genes provide instructions for making a protein called alpha-globin, which is a component of hemoglobin.
  • This article on has been reviewed by a medical professional, as well as checked for facts, to assure the readers the best possible accuracy.
  • Explain the importance of improving care coordination amongst the interprofessional team to enhance the delivery of care for patients with alpha-thalassemia.

(With aging patients, a transfusion every two weeks may be necessary.) Transfusions should be scheduled in advance and maintained at a fixed schedule. This enables patients and families to establish routines and will improve quality of life. Although the hemoglobin level can define a patient’s disease type, seldom does it alone determine the need for transfusion. Antibodies to hepatitis B, hepatitis C, and HIV should also be determined. Patients should demonstrate immunity to hepatitis B.

Condition Details

Babies with this type usually die before they are born. I only know thal minors who are donating blood to get the ferritin down. Some people with thalassemia may need their spleen removed.


A person with thalassemia minor has a 25% chance of having a baby with thalassemia major if his/her mate also has thalassemia minor. Current treatments allow thalassemia patients to live relatively normal lives, however, a cure remains to be found. The genetic cause of thalassemia was one of the first genes discovered in the 1970’s, yet 30 years later, gene therapy still eludes thalassemia patients. The decision to start regular transfusions is clear when the initial hemoglobin level is well below 6 g/dL. To assess a child’s need for routine transfusions due to thalassemia, anemia caused by sepsis or viral infection must be ruled out.

Doctors can diagnose silent carriers with genetic testing. Alpha thalassemia is an inherited condition that requires both parents to be carriers. Therefore, the risk of having a child with alpha thalassemia disease depends on the status of the parents. Annual transfusion volume exceeding 225 to 250 mL/kg per year with packed red blood cells may indicate the presence of hypersplenism. The volume calculation should be corrected if the average hematocrit is less than 75 percent. The possible development of alloantibody should also be ruled out.

What Are the Signs & Symptoms of Hemoglobin H Disease or Alpha Thalassemia Major?

Remember that the iron found in meat is much more easliy absorbed than other sources of iron, such as cereals and breads. The alpha / beta and alpha 2 / alpha 1-globin mRNA ratios in different forms of alpha-thalassemia. Genetic counseling is mandatory for young patients willing to conceive. Patients should be educated about the consequences of iron overload and the importance of adherence to treatment. Clinical presentation usually starts in the latter part of gestation with hemolytic anemia due to the formation of HbBarts.