Can Thalassemia Carrier Donate Blood

Thalassemia: What It Is & Can A Person Suffering From It Donate Blood Healthians

However, some studies show that those having thalassemia may be at an increased risk of getting blood cancers and abdominal cancer than those who are not affected by this disorder. With appropriate investigations, thalassemia, its type and severity can be diagnosed. Routine blood tests can detect anaemia but more specialised tests help to diagnose thalassemia.

  • Those with thalassemia major usually show symptoms within the first two years of life.
  • He or she can also donate blood to others if they have the international criteria of normal levels of hemoglobin.
  • Thalassemia is actually a group of inherited diseases of the blood that affect a person’s ability to produce hemoglobin, resulting in anemia.
  • In people suffering from thalassemia major both the genes are mutated .
  • People with thalassemia minor can still have thalassemia major children.

If both parents are thalassemia carriers, their children will have thalassemia. Major thalassemia is very serious and may affect their growth, liver, heart and bone. People who are carriers of thalassaemia are also at risk of having a child with a blood disorder if their partner is a carrier of a different type of blood disorder. If one parent is a thalassemia carrier and other is normal, then their child will not have thalassemia major. There is a possibility that their child can be a carrier of thalassemia.

A woman who is a thalassemia carrier can conceive normally but she might have to take more iron supplements than normal during pregnancy. He or she can also donate blood to others if they have the international criteria of normal levels of hemoglobin. They can also donate stem cells or bone marrow to their deceased sibling. Some thalassemia carriers may suffer from some very small symptoms of anemia due to the small size of the red blood cells. The medical history is taken into account and tests are carried out to make sure that the person does not have anaemia.

People with thalassemia minor can still have thalassemia major children. If both parents are thalassemia carriers, their genes can be passed on and the child born can have thalassemia major. If one parent has the gene, there is a risk of having thalassemia minor child. In a milder or minor form of thalassemia, the symptoms are either very mild anemia or not visible at all. The recommended treatment for thalassaemia major involves lifelong regular blood transfusions, usually administered every two to five weeks, to maintain the pretransfusion haemoglobin level above 9–10.5 g/dl.

When it finds these infections, it can start the process of fighting them. When you have thalassemia, the spleen can get very big as it tries to make blood cells. Because it is working so hard on this job, it can’t work as hard to filter blood or monitor for and fight infections. Because of this, people with thalassemia are said to be “immunocompromised,” which means that some of the body’s defenses against infection aren’t working.

A new technique, pre-implantation genetic diagnosis , used in conjunction with in vitro fertilization, may enable parents who have thalassemia or carry the trait to give birth to healthy babies. Embryos created in-vitro are tested for the thalassemia gene before being implanted into the mother, allowing only healthy embryos to be selected. A child who inherits two thalassemia trait genes – one from each parent – will have the disease. A child of two carriers has a 25 percent chance of receiving two trait genes and developing the disease, and a 50 percent chance of being a thalassemia trait carrier. Another concern for people who receive a lot of blood transfusions is the safety of the blood they receive.

Eating nutritious foods is important for everyone to maintain a healthy lifestyle – a diet, high in fruits and vegetables and low in fats is ideal for gaining the essential nutrients our bodies need. For people living with thalassemia, because too much iron may build up in the blood, foods high in iron may need to be limited. Iron can be found in meat, fish, and some vegetables (e.g., spinach). Other products, like cereal and orange juice, may contain extra iron. Persons with thalassemia should discuss with their doctor whether or not they should limit the amount of iron in their diet.

If you have thalassemia, you should discuss with your doctor the level of exercise that would be best for you. If you carry thalassaemia, you will not ever develop thalassaemia, but you may sometimes experience mild anaemia. In thalassemia minor only one gene is mutated , which makes the person a thalassemia carrier and thus is less prone to the severe form of the disease. People with moderate and severe forms of thalassemia usually find out about their condition in childhood, since they have symptoms of severe anemia early in life. People with less severe forms of thalassemia may only find out because they are having symptoms of anemia, or maybe because a doctor finds anemia on a routine blood test or a test done for another reason.

Can a person with the thalassaemia minor trait donate blood?

If you’re a carrier of thalassaemia, it means you carry one of the faulty genes that cause thalassaemia, but you do not have thalassaemia yourself. Because thalassemias are inherited, the condition sometimes runs in families. Some people find out about their thalassemia because they have relatives with a similar condition. The information on this website is for educational purposes only and is not intended to substitute for informed medical advice. You should not use this information to diagnose or treat a health problem or disease without consulting a qualified health care provider.

Out of 738 samples, 85 samples were excluded from the study since the samples were inadequate for DNA analysis. Five hundred twelve (512/653; 78.4%) samples were within normal limits and 74 (74/653; 11.3%) samples with Hb less than 12.5 g/dl; whose four (4/74; 5.4%) of them had haemoglobinopathies. Low mean corpuscular haemoglobin value was observed in 225 (225/653; 34.5%) donors, of whom 37 (37/225; 16.4%) had haemoglobinopathies. Haemoglobinopathy was found in one (1/653; 0.1%) donor with normal MCH (28.2 pg) and low mean corpuscular volume value . There were four (4/653; 6.1%) donors with Hb Constant Spring, two of them were detected to have Hb Constant Spring only by using two methods, ie. CE and alkaline gel electrophoresis, which was in contrast to our previous report .

In people suffering from thalassemia major both the genes are mutated . However, in thalassemia minor only one gene is mutated , which makes the person a thalassemia carrier. Thalassemia major is more serious with severe anaemia, while thalassemia minor is mild. Thalassemia is a genetic disorder which makes it impossible to prevent and eventually leads to anaemia. The impact of this disorder can range between mild, severe to life threatening. For a thalassemic person to survive regular blood transfusions is an absolute necessity.

The blood is not suitable for intrauterine transfusion or neonatal exchange transfusion. It may also exacerbate the red cells sickling in those with sickle cell disease which ultimately cause sickling crisis . Countries in Southeast Asia have extremely high prevalence of haemoglobin E; the frequency is widely varies from 3 to 60% [7-9]. The incidence of Hb E among our blood donors is 3.9%, while in Thailand is 5.2% .

How do blood transfusions affect my body?

Genetic counselling of families with thalassemia, helps in identifying the risk of passing the defect to their children. Pregnant women can undergo prenatal testing to evaluate the chances of thalassemia in the baby. Blood tests and family genetic studies can show whether an individual has thalassemia or is a carrier.

When it builds up, the iron collects in places like the heart, liver, and brain, and can make it hard for these organs to work properly. To prevent iron overload, people with thalassemia may need chelation therapy, which is when doctors give a medicine – either a pill or a shot under the skin – to remove excess iron before it builds up in the organs. It is a common practice worldwide to accept blood from thalassemic carrier donors who meet the minimum Hb level for blood donation . However, the exception is not applied to Hb S carrier; neither apheresis nor whole blood donations are allowed.

But surprisingly, some types of Thalassemia patients can still donate blood. Hemoglobin, which carries oxygen to all cells in the body, is made of two different parts, called alpha and beta. When thalassemia is called “alpha” or “beta,” this refers to the part of hemoglobin that isn’t being made.

A genetic counsellorwill discuss the result and implications with you if you’re found to have the trait. You can have a blood test to see if you’re a carrier if you think you may be at risk. The NHS Sickle Cell and Thalassaemia Screening Programme also has detailed leaflets about being abeta thalassaemia carrier or a delta beta thalassaemia carrier. Which is y, normally thal patient’s blood would not pass to go into blood bank..

If your baby has one parent with thalassaemia minor, he has a 50 per cent chance of inheriting the gene defect and being a carrier like his parent. If both your baby’s parents have thalassaemia minor, he could have a double dose of the gene and have the more severe thalassaemia major. Much worse during inactive contraception pills.i have pcos and alpha thalassemia trait. In the case of individuals with the alpha-thalassemia type, the results often show a small red blood cell count with a normal ratio of both hemoglobin A2 and hemoglobin F.

Thalassemia can be prevented by awareness, pre-Marital / pre-conceptual screening followed by antenatal diagnosis is required. There are over 35 million Indians are carriers of the abnormal Gene for Thalassemia. Having warm, supportive relationships is an important part of life. This can cause symptoms such as tiredness and pale skin, but may only be picked up with a blood test.