Factor V Leiden Diagnosis and treatment
In the U.S., FVL is present in approximately 5% of the general population. It is less common in Native Americans and African-Americans than in those of Northern European ancestry. Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Rather, it’s key to keep your intake of the nutrient consistent.
- The death of my grandmother from a stroke, most likely the result of a clot, and the future of my family spur me on to increase awareness, research, and treatment of blood clots and blood clotting disorders.
- There is more risk of a blood clot if both gene codes are for Factor V Leiden .
- Factor V is a protein, also known as a clotting or coagulation factor, that’s needed for blood to clot properly.
- HealthTap doctors are based in the U.S., board certified, and available by text or video.
- Both factor V Leiden and a prothrombin gene mutation do not have symptoms on their own, and some people may never know that they have them.
Is it still possible to get blood clots while on warfarin? Video chat with a U.S. board-certified doctor 24/7 in a minute. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. Your doctor may perform other tests to rule out additional factors, like lupus, that may be contributing to excessive clotting.
Other Risk Factors for Blood Clots
My grandmother may have had an undiagnosed clotting disorder. She died approximately 20 years before a genetic test was available. If nothing else, I want my children to accept having a blood clotting disorder, not to fear it. Doctors generally prescribe blood-thinning medications to treat people who develop abnormal blood clots. This type of medicine usually isn’t needed for people who have the factor V Leiden mutation but who have not experienced abnormal blood clots. Inheriting the genetic mutation from both parents instead of just one can significantly increase your risk of abnormal blood clots.
People with Factor V Leiden who’ve never had a blood clot won’t be routinely treated with anticoagulation medications unless there are other medical issues or life events that may warrant it. People with Factor V Leiden who have a history of recurrent blood clotting are generally treated with anticoagulation medications for life. Thrombophilia is defined as an increased tendency to form abnormal blood clots that can block blood vessels. Factor V Leiden is a change in your genes that affects one of the clotting factors in your blood and keeps your body’s blood-clotting process from working right.
Heart-healthy foods help reduce inflammation and may help you get to a healthy weight, both of which are necessary for healthy blood, per Johns Hopkins Medicine. That’s important because high blood pressure can damage blood vessels, increasing blood clot risk. The normal blood clotting process goes to work right away when you get a cut — platelets rush to the site to seal it, and a substance called fibrin — aided by factor V — helps the platelets to form a clot. Usually, once the clot is formed, factor V is "turned off," but not in those with factor V Leiden.
The mutation is named factor V “Leiden” because it was originally discovered at the University of Leiden in the Netherlands, in 1994. Make a list of all medications, vitamins or supplements you’re taking, along with the dose for each. List any symptoms you’re experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
When Would I Need to Get Tested for the Mutation?
This differential effect of Factor V Leiden on the risk for these 2 types of vein clots is known as the “Factor V Leiden paradox”. You make a protein called factor V that helps your blood clot. However, if you have a DNA mutation in the gene used to make the factor V protein, you have the “factor V Leiden” mutation. The mutation was named after a city called Leiden, where they did research on the first family found to have the mutation. If you have the factor V Leiden mutation, you have an inherited thrombophilia or clotting disorder. People who have the genetic disorder called Factor V Leiden are more likely than others to develop blood clots.
Talk to a primary care doctor now for a personalized answer to your Hematology question
When people who have FVL develop any symptoms, these will be related to DVT and PE, so it is important to recognize the symptoms of DVT or PE. Both of these conditions are medical emergencies. FVL can only be inherited from a parent who has the mutation, which is more common among individuals of Northern European ancestry. Children from a parent with heterozygous FVL mutation have a 25% chance of having inherited it from the parent who has the mutation. The best diet to follow is one full of foods that support heart health, because these are also naturally good for your blood health.
If you want to increase the amount you’re eating, your doctor can help you make the adjustment slowly, with appropriate adjustments to your medication. A simple blood test can show if you have Activated Protein C resistance. If you do, another blood test that examines your Factor V gene will be done to find out if Factor V Leiden is the cause of the resistance and what type of Factor V Leiden you have. Factor V Leiden thrombophilia is caused by a specific mutation in the Factor V gene. Factor V Leiden should not be confused with Factor V deficiency. Factor V deficiency is an inherited bleeding disorder that can cause excessive bleeding.